|Voiced by||Ryoko Sugizaki|
Yukie Kobe (河辺幸江 Kōbe Yukie?) is a character in Siren: Blood Curse. She was a nurse at Saiga hospital and Seigo's fiancee. She always followed him around and called him "sensei" or "doctor", which became her catchphrase. She was used as the first sacrifice during the ritual at the beginning of the game and Seigo killed her by stabbing her through the heart with Homuranagi. Melissa Gale, Sam Monroe, Sol Jackson and Howard Wright wittnessed her death, but were unable to save her. She rose as Shibito and became the first Shibito in town and somewhat of a leader among them. She and other Shibito attacked humans and she began stalking and pursuing Seigo everywhere. She finds an arguing americans and approaches them laughing as the sound of a siren pierces the air. She follows Bella to the hospital and searches for her there. She meets and confronts Melissa when she comes to the hospital searching for Bella. She later becomes a Shibito Brain herself and meets and stalks Seigo in the mines when he goes there to search for Uryen. After Sam and Melissa leave to go find Bella, Yukie exits the hospital and approaches Seigo once again, calling out for him. He shoots her down and then shoots himself after saying, "I'm getting tired of this." Seigo says her name as his last words as he dies in the second timeline, killed by Howard.
- While her voice is provided by Ryoko Sugizaki, her model is provided by Chiang Li-mei.